SELECTED ARTICLES
Recent Publications
2024
1. Urso A, Monk IR, Chen YT, Predella C, Wong Fok Lung T, Theiller EM, Boylan J, Perelman S, Baskota SU, Moustafa AM, Lohia GK, Lewis, IA, Howden BP, Stinear TP, Dorrello NV, Torres V, Prince AS. (2024). Staphylococcus aureus adapts to exploit collagen-dervied proline during chronic infection. Nature Microbiology. https://doi.org/10.1038/s41564-024-01769-9
2. Prince A. (2024). Immunometabolites direct the pathogenesis of bacterial infection. Journal of Innate Immunity. https://doi.org/10.1159/000540093
3. Bhushan G, Castano V, Wong Fok Lung T, Chandler C, McConville TH, Ernst RK, Prince AS, Ahn D. (2024). Lipid A modification of colistin-resistant Klebsiella pneumoniae does not alter innate immune response in a mouse model of pneumonia. Infection and Immunity. https://doi.org/10.1128/iai.00016-24
2023
1. Tomlinson KL, Riquelme SA, Baskota SU, Drikic M, Monk IR, Stinear TP, Lewis, IA, Prince AS. (2023). Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst. Cell Reports. https://doi.org/10.1016/j.celrep.2023.112064
2. Tomlinson KL, Chen YT, Junker A, Urso A, Wong Fok Lung T, Ahn D, Hofstaedter CE, Baskota SU, Ernst RK, Prince AS, Riquelme SA. (2023). Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection. Cell Metabolism. https://doi.org/10.1016/j.cmet.2023.09.001
2022
1. Wong Fok Lung T, Chan LC, Prince A, Yeaman MR, Archer NK, Aman MJ, Proctor RA. (2022). Staphylococcus aureus adaptive evolution: Recent insights on how immune evasion, immunometabolic subversion and host genetics impact vaccine development. Frontiers in Cellular and Infection Microbiology; https://doi.org/10.3389/fcimb.2022.1060810
2. Urso A and Prince A. (2022). Anti-Inflammatory Metabolites in the Pathogenesis of Bacterial Infection. Frontiers in Cellular and Infection Microbiology; https://doi.org/10.3389/fcimb.2022.925746
3. Wong Fok Lung T, Charytonowicz D, Beaumont KG, Shah S, Sridhar SH, Gorrie CL, Mu A, Hofstaedter CE, Varisco D, McConville TH, Drikic M, Fowler B, Urso A, Shi W, Fucich D, Annavajhala MK, Khan IN, Oussenko I, Francoeur N, Smith ML, Stockwell BR, Lewis IA, Hachani A, Baskota SU, Uhlemann AC, Ahn D, Ernst RK, Howden BP, Sebra R, Prince A. (2022). Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection. Cell Metabolism; doi: 10.1016/j.cmet.2022.03.009
4. Rosenberg G, Riquelme S, Prince A, Avraham R. (2022). Immunometabolic crosstalk during bacterial infection. Nature Microbiology; doi.org/10.1038/s41564-022-01080-5
2021
1. Riquelme S, Prince A. (2021). Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection. Pathogens, 10(8), 957; doi.org/10.1038/s41564-022-01080-5
2. Ahn D, Bhushan G, McConville TH, Annavajhala MK, Soni RK, Wong Fok Lung T, Hofstaedter CE, Shah SS, Chong AM, Castano VG, Ernst RK, Uhlemann AC, Prince A. (2021). An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection. Cell Report Jun 1;35(9):109196. doi: 10.1016/j.celrep.2021.109196. PMID: 34077733.
3. Tomlinson, K., Wong Fok Lung, T., Dach, F., Annavajhala, M., Gabryszewski, S., Groves, R., Drikic, M., Francoeur, N., Sridhar, S., Smith, M., Khanal, S., Britto, C., Sebra, R., Lewis, I., Uhlemann, A., Kahl, B., Prince, A., Riquelme, S. (2021). Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation. Nature Communications. doi: 10.1038/s41467-021-21718-y.
4. Shah, S., Fidock, D., & Prince, A. (2021). Hemozoin promotes lung inflammation via host epithelial activation. mBio. doi: 10.1128/mBio.02399-20.
2020
1. Riquelme, S., Liimatta, K., Wong Fok Lung, T., Fields, B., Ahn, D., & Chen, D. et al. (2020). Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation. Cell Metabolism. doi: 10.1016/j.cmet.2020.04.017
2. Riquelme, S., Wong Fok Lung, T., & Prince, A. (2020). Pulmonary Pathogens Adapt to Immune Signaling Metabolites in the Airway. Frontiers In Immunology, 11. doi: 10.3389/fimmu.2020.00385
3. Ahn, D., & Prince, A. (2020). Participation of the IL-10RB related cytokines, IL-22 and IFN-Lambda in defense of the airway mucosal barrier. Frontiers In Cellular And Infection Microbiology. doi: 10.3389/fcimb.2020.00300
2019
1. Acker, K., Wong Fok Lung, T., West, E., Craft, J., Narechania, A., & Smith, H. et al. (2019). Strains of Staphylococcus aureus that Colonize and Infect Skin Harbor Mutations in Metabolic Genes. iScience, 19, 281-290. doi: 10.1016/j.isci.2019.07.037
2. Riquelme, Sebastián & Lozano, Carmen & Moustafa, Ahmed M & Liimatta, Kalle & Tomlinson, Kira & Britto, Clemente & Khanal, Sara & K Gill, Simren & Narechania, Apurva & Azcona-Gutiérrez, José & Dimango, Emily & Sáenz, Yolanda & Planet, Paul & Prince, Alice. (2019). CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection. Science Translational Medicine. 11. 10.1126/scitranslmed.aav4634.
3. J. Gabryszewski, Stanislaw & Wong Fok Lung, Tania & Annavajhala, Medini & Tomlinson, Kira & Riquelme, Sebastián & N Khan, Ibrahim & Noguera, Loreani & Wickersham, Matthew & Zhao, Alison & M. Mulenos, Arielle & Peaper, David & Koff, Jon & Uhlemann, Ac & Prince, Alice. (2019). Metabolic Adaptation in MRSA Pneumonia. American Journal of Respiratory Cell and Molecular Biology. 10.1165/rcmb.2018-0389OC.
4. P. Acker, Karen & Wong Fok Lung, Tania & West, Emily & Craft, Joshua & Narechania, Apurva & Smith, Hannah & O’Brien, Kelsey & Moustafa, Ahmed M & Lauren, Christine & Planet, Paul & Prince, Alice. (2019). Metabolic Adaptation Drives Staphylococcus aureus Colonization and Infection of the Skin. SSRN Electronic Journal. 10.2139/ssrn.3344568.
2018
1. Acker, K., Wong, T., West, E. S., Planet, P., & Prince, A. (2018). 625. Metabolic Interactions Drive Staphylococcus aureus Adaptation to the Skin. Open Forum Infectious Diseases, 5(Suppl 1), S228. doi:10.1093/ofid/ofy210.632
2. Ahn D, Wickersham M, Riquelme S, Prince A. (2018). The Effects of IFN-λ on Epithelial Barrier Function Contribute to K. pneumoniae ST258 Pneumonia. American Journal Respiratory Cell and Molecular Biology. Sep 5. doi: 10.1165/rcmb.2018-0021OC. PMID: 30183325
3. Riquelme S.A, Ahn D, Prince A. (2018). Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. Journal of Innate Immunity. 2018 Apr 4. doi: 10.1159/000487515. PMID: 29617698
2017
1. Riquelme S.A., Hopkins B.D., Wolfe A.L., DiMango E., Kitur K., Parsons R., Prince A. (2017). Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity. Immunity. 2017 Dec 19;47(6):1169-1181.e7. doi: 10.1016/j.immuni.2017.11.010. PMID: 29246444
2. Ahn, D., & Prince, A. (2017). Host-Pathogen Interface: Progress in Understanding the Pathogenesis of Infection Due to Multidrug-Resistant Bacteria in the Intensive Care Unit. Journal of Infectious Diseases. 2017 Feb 15;215(suppl_1):S1-S8. doi:10.1093/infdis/jiw405.
3. Wickersham M., Wachtel S., Wong Fok Lung T., Soong G., Jacquet R., Richardson A., Parker D., & Prince A. (2017). Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection. Cell Report. 2017 Mar 14;18(11):2742-2751. doi: 10.1016/j.celrep.2017.02.055.
2016
1. Ahn, D., Peñaloza, H., Wang, Z., Wickersham, M., Parker, D., Patel, P., Koller, A., Chen, E., Bueno, S., Uhlemann, A.C. & Prince, A. (2016). Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection. JCI Insight. 2016;1(17):e89704. doi:10.1172/jci.insight.89704.
2. Parker, D., & Prince, A. (2016). Immunoregulatory effects of necroptosis in bacterial infections. Cytokine, 88, 274. PMID: 27710879
3. Prince, A., Wang, H., Kitur, K., & Parker, D. (2016). Humanized mice exhibit increased susceptibility to Staphylococcus aureus pneumonia. Journal of Infectious Diseases. PMID: 27638942
4. Kitur, Kipyegon, Sarah Wachtel, Armand Brown, Matthew Wickersham, Franklin Paulino, Hernán F. Peñaloza, Grace Soong, Susan Bueno, Dane Parker, and Alice Prince. (2016) Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling. Cell Reports. PMID: 27524612
5. Planet, P. J., Parker, D., Cohen, T. S., Smith, H., Leon, J. D., Ryan, C., ... & Prince, A. S. (2016). Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection. mBio,7(1), e01939-15. PMID: 26861017
6. Parker, D., & Prince, A. (2016). A new approach to toxin neutralization in Staphylococcus aureus therapy. EMBO reports, 17(3), 284-285. PMID: 26882555
7. Parker, D., Ahn, D., Cohen, T., & Prince, A. (2016). Innate Immune Signaling Activated by MDR Bacteria in the Airway. Physiological Reviews, 96(1), 19-53. PMID: 26582515
2015
1. Soong G, Paulino F, Wachtel S, Parker D, Wickersham M, Zhang D, Brown A, Lauren C, Dowd M, West E, Horst B, Planet P, Prince A. Methicillin-resistant Staphylococcus aureus adaptation to human keratinocytes. mBio. 2015 Apr 21;6(2). PMID: 25900653
2. Kitur K, Parker D, Nieto P, Ahn DS, Cohen TS, Chung S, Wachtel S, Bueno S, Prince A. Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage. PLoS Pathogen. 2015 Apr 16;11(4):e1004820. PMID: 25880560
2014
1. Parker, D, Ryan, C, Alonzo, F, Torres, V, Planet, P and Prince, A. (2014). CD4+ T cells contribute to the pathogenesis of MRSA pneumonia. Journal of Infectious Disease. 2015 Mar 1;211(5):835-45. doi: 10.1093/infdis/jiu525. Epub 2014 Sep 19.
2. Ahn D, Parker D, Planet P and Prince A. Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia. Mucosal Immunology. 2014 Nov;7(6):1366-74. doi: 10.1038/mi.2014.24. Epub 2014 Apr 16.
3. Parker D, Narechania A, Sebra R, Deikus G, LaRussa S, Ryan C, Smith H, Prince A, MAthema B, Ratner AJ, Kreishwirth B and Planet PJ. Genome Sequence of Bacterial Interference Strain Staphylococcus aureus 502A. Genome Announcements 2014; 2(2): e00284-14. PMCID: PMC3983310
4. Parker D, Planet PJ, Soong G, Narechania A, and Prince A. Induction of type I interferon signaling determines the relative pathogenicity of Staphylococcus aureus strains. PLoS Pathogen. 2014;10(2):e1003951. PMCID: PMC3930619
5. Westphalen K, Gusarova GA, Islam MN, Subramanian M, Cohen TS, Prince AS, Bhattacharya J. Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature. 2014; Jan 19. doi: 10.1038/nature12902. PMID: 24463523
2013
1. Planet PJ, LaRussa SJ, Dana A, Smith H, Xu A, Ryan C, Uhlemann AC, Boundy S, Goldberg J, Narechania A, Kulkarni R, Ratner AJ, Geoghegan JA, Kolokotronis SO, Prince A. Emergence of the epidemic methicillin-resistant Staphylococcus aureus strain USA300 coincides with horizontal transfer of the arginine catabolic mobile element and speG-mediated adaptations for survival on skin. mBio. 2013; Dec 17;4(6):e00889-13. doi: 10.1128/mBio.00889-13. PMID: 24345744
2. Cohen TS, Prince A. Bacterial pathogens activate a common inflammatory pathway through IFNλ regulation of PDCD4. PLoS Pathogen. 2013; 9(10):e1003682. doi: 10.1371/journal.ppat.1003682. PMID: 24098127
3. Parker D, Prince A. Epithelial uptake of flagella initiates proinflammatory signaling. PLoS One. 2013;8(3):e59932. PMCID: PMC3603936
4. Cohen TS, Prince A. Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia. Journal Clinical Investigation. 2013;123(4):1630-7. PMCID: PMC3613922
2012
1. Parker D, Prince A. Staphylococcus aureus Induces Type I IFN Signaling in Dendritic Cells Via TLR9. Journal of Immunology. 2012 Oct 15;189(8):4040-6. PMCID: PMC3466375
2. Cohen TS, Prince A. Cystic fibrosis: a mucosal immunodeficiency syndrome. Nature Medicine. 2012 Apr 5;18(4):509-19. PMCID: PMC3577071
3. Soong G, Chun J, Parker D, Prince A. Staphylococcus aureus activation of caspase-1/calpain signaling mediates invasion through human keratinocytes. Journal of Infectious Disease. 2012 May;205(10):1571-9. PMCID: PMC3415815
4. Parker D, Prince A. Immunopathogenesis of Staphylococcus aureus pulmonary infection. Seminar Immunopathology 2012 Mar;34(2):281-97. PMCID: PMC3577067
5. Parker D, Cohen TS, Alhede M, Harfenist BS, Martin FJ, Prince A. Induction of Type I Interferon Signaling by Pseudomonas aeruginosa is Diminished in Cystic Fibrosis Epithelial Cells. American Journal Respiratory Cell and Molecular Biology. 2012 Jan;46(1):6-13. PMCID: PMC3262660
2011
1. Parker D, Prince A. Type I interferon response to extracellular bacteria in the airway epithelium. Trends Immunol. 2011 Dec;32(12):582-8. PMCID: PMC3221817
2. Soong, G., F. J. Martin, J. Chun, T. S. Cohen, D. S. Ahn, and A. Prince. Staphylococcus aureus protein A mediates invasion across airway epithelial cells through activation of RhoA signaling and proteolytic activity. Journal of Biological Chemistry. 2011. Oct 14; 286(41):35891-8. PMCID: PMC3195615
3. Parker D, Martin FJ, Soong G, Harfenist BS, Aguilar JL, Ratner AJ, Fitzgerald KA, Schindler C, Prince A. Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract. mBio. 2011 May 17;2(3). doi: e00016-11. PMCID: PMC3101776
4. Martin FJ, Parker D, Harfenist BS, Soong G, Prince A. Participation of CD11c+ leukocytes in the host response to MRSA infection of the lung. Infection and Immunity. 2011 79(5):1898-904. PMCID: PMC3088152
5. Parker, D and Prince A. Innate Immunity in the epithelium. American Journal Respiratory Cell and Molecular Biology. 2011 45(2):189-201. PMCID: PMC3175551