Recent Publications:

Urso A and Prince S. (2022). Anti-Inflammatory Metabolites in the Pathogenesis of Bacterial Infection. Fronteirs in Cellular and Infection Microbiology

Wong Fok Lung T, Charytonowicz D, Beaumont KG, Shah S, Sridhar SH, Gorrie CL, Mu A, Hofstaedter CE, Varisco D, McConville TH, Drikic M, Fowler B, Urso A, Shi W, Fucich D, Annavajhala MK, Khan IN,  Oussenko I, Francoeur N, Smith ML, Stockwell BR, Lewis IA, Hachani A, Baskota SU, Uhlemann AC, Ahn D, Ernst RK, Howden BP, Sebra R, Prince A. (2022). Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection. Cell Metabolism; 

doi: 10.1016/j.cmet.2022.03.009

Rosenberg G, Riquelme S, Prince A, Avraham R. (2022). Immunometabolic crosstalk during bacterial infection. Nature Microbiology;

Riquelme S, Prince A. (2021). Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection.  Pathogens, 10(8), 957;

Ahn D, Bhushan G, McConville TH, Annavajhala MK, Soni RK, Wong Fok Lung T, Hofstaedter CE, Shah SS, Chong AM, Castano VG, Ernst RK, Uhlemann AC, Prince A. An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection. Cell Rep. 2021 Jun 1;35(9):109196. doi: 10.1016/j.celrep.2021.109196. PMID: 34077733.

Tomlinson, K., Wong Fok Lung, T., Dach, F., Annavajhala, M., Gabryszewski, S., Groves, R., Drikic, M., Francoeur, N., Sridhar, S., Smith, M., Khanal, S., Britto, C., Sebra, R., Lewis, I., Uhlemann, A., Kahl, B., Prince, A. & Riquelme, S. (2021). Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation.  Nature Communications. doi: 10.1038/s41467-021-21718-y.

Shah, S., Fidock, D., & Prince, A. (2021). Hemozoin promotes lung inflammation via host epithelial activation. mBio. doi: 10.1128/mBio.02399-20.

Riquelme, S., Liimatta, K., Wong Fok Lung, T., Fields, B., Ahn, D., & Chen, D. et al. (2020). Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation. Cell Metabolism. doi: 10.1016/j.cmet.2020.04.017

Riquelme, S., Wong Fok Lung, T., & Prince, A. (2020). Pulmonary Pathogens Adapt to Immune Signaling Metabolites in the Airway. Frontiers In Immunology, 11. doi: 10.3389/fimmu.2020.00385

Ahn, D., & Prince, A. (2020). Participation of the IL-10RB related cytokines, IL-22 and IFN-Lambda in defense of the airway mucosal barrier. Frontiers In Cellular And Infection Microbiology. doi: 10.3389/fcimb.2020.00300

Wong Fok Lung, T., Monk, I., Acker, K., Mu, A., Wang, N., & Riquelme, S. et al. (2019). Staphylococcus aureus small colony variants impair host immunity by activating host cell glycolysis and inducing necroptosis. Nature Microbiology. doi: 10.1038/s41564-019-0597-0

Acker, K., Wong Fok Lung, T., West, E., Craft, J., Narechania, A., & Smith, H. et al. (2019). Strains of Staphylococcus aureus that Colonize and Infect Skin Harbor Mutations in Metabolic Genes. Iscience, 19, 281-290. doi: 10.1016/j.isci.2019.07.037


Riquelme, Sebastián & Lozano, Carmen & Moustafa, Ahmed M & Liimatta, Kalle & Tomlinson, Kira & Britto, Clemente & Khanal, Sara & K Gill, Simren & Narechania, Apurva & Azcona-Gutiérrez, José & Dimango, Emily & Sáenz, Yolanda & Planet, Paul & Prince, Alice. (2019). CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection. Science Translational Medicine. 11. 10.1126/scitranslmed.aav4634. 


J. Gabryszewski, Stanislaw & Wong Fok Lung, Tania & Annavajhala, Medini & Tomlinson, Kira & Riquelme, Sebastián & N Khan, Ibrahim & Noguera, Loreani & Wickersham, Matthew & Zhao, Alison & M. Mulenos, Arielle & Peaper, David & Koff, Jon & Uhlemann, Ac & Prince, Alice. (2019). Metabolic Adaptation in MRSA Pneumonia. American Journal of Respiratory Cell and Molecular Biology. 10.1165/rcmb.2018-0389OC. 


P. Acker, Karen & Wong Fok Lung, Tania & West, Emily & Craft, Joshua & Narechania, Apurva & Smith, Hannah & O’Brien, Kelsey & Moustafa, Ahmed M & Lauren, Christine & Planet, Paul & Prince, Alice. (2019). Metabolic Adaptation Drives Staphylococcus aureus Colonization and Infection of the Skin. SSRN Electronic Journal. 10.2139/ssrn.3344568.

Acker, K., Wong, T., West, E. S., Planet, P., & Prince, A. (2018). 625. Metabolic Interactions Drive Staphylococcus aureus Adaptation to the Skin. Open Forum Infectious Diseases, 5(Suppl 1), S228. doi:10.1093/ofid/ofy210.632

Ahn D, Wickersham M, Riquelme S, Prince A. (2018). The Effects of IFN-λ on Epithelial Barrier Function Contribute to K. pneumoniae ST258 Pneumonia. Am J Respir Cell Mol Biol. 2018 Sep 5. doi: 10.1165/rcmb.2018-0021OC. PMID: 30183325

Riquelme S.A, Ahn D, Prince A. (2018). Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018 Apr 4. doi: 10.1159/000487515. PMID: 29617698


Riquelme S.A., Hopkins B.D., Wolfe A.L., DiMango E., Kitur K., Parsons R., Prince A. (2017). Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity. Immunity. 2017 Dec 19;47(6):1169-1181.e7. doi: 10.1016/j.immuni.2017.11.010. PMID: 29246444

Ahn, D., & Prince, A. (2017). Host-Pathogen Interface: Progress in Understanding the Pathogenesis of Infection Due to Multidrug-Resistant Bacteria in the Intensive Care Unit. J Infect Dis. 2017 Feb 15;215(suppl_1):S1-S8. doi:10.1093/infdis/jiw405.

Wickersham M., Wachtel S., Wong Fok Lung T., Soong G., Jacquet R., Richardson A., Parker D., & Prince A. (2017). Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection. Cell Rep. 2017 Mar 14;18(11):2742-2751. doi: 10.1016/j.celrep.2017.02.055.


Ahn, D., Peñaloza, H., Wang, Z., Wickersham, M., Parker, D., Patel, P., Koller, A., Chen, E., Bueno, S., Uhlemann, A.C. & Prince, A. (2016). Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection. JCI Insight. 2016;1(17):e89704. doi:10.1172/jci.insight.89704.

Parker, D., & Prince, A. (2016). Immunoregulatory effects of necroptosis in bacterial infections. Cytokine, 88, 274. PMID: 27710879

Prince, A., Wang, H., Kitur, K., & Parker, D. (2016). Humanized mice exhibit increased susceptibility to Staphylococcus aureus pneumonia. Journal of Infectious Diseases. PMID: 27638942​

Kitur, Kipyegon, Sarah Wachtel, Armand Brown, Matthew Wickersham, Franklin Paulino, Hernán F. Peñaloza, Grace Soong, Susan Bueno, Dane Parker, and Alice Prince. (2016) Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling. Cell Reports. PMID: 27524612

Planet, P. J., Parker, D., Cohen, T. S., Smith, H., Leon, J. D., Ryan, C., ... & Prince, A. S. (2016). Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection. mBio,7(1), e01939-15. PMID: 26861017

Parker, D., & Prince, A. (2016). A new approach to toxin neutralization in Staphylococcus aureus therapy. EMBO reports, 17(3), 284-285. PMID: 26882555

Parker, D., Ahn, D., Cohen, T., & Prince, A. (2016). Innate Immune Signaling Activated by MDR Bacteria in the Airway. Physiological Reviews, 96(1), 19-53. PMID: 26582515


Soong G, Paulino F, Wachtel S, Parker D, Wickersham M, Zhang D, Brown A, Lauren C, Dowd M, West E, Horst B, Planet P, Prince A. Methicillin-resistant Staphylococcus aureus adaptation to human keratinocytes. MBio. 2015 Apr 21;6(2). PMID: 25900653


Kitur K, Parker D, Nieto P, Ahn DS, Cohen TS, Chung S, Wachtel S, Bueno S, Prince A. Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage. PLoS Pathog. 2015 Apr 16;11(4):e1004820. PMID: 25880560 


Parker, D, Ryan, C, Alonzo, F, Torres, V, Planet, P and Prince, A. (2014). CD4+ T cells contribute to the pathogenesis of MRSA pneumonia. J Infect Dis. 2015 Mar 1;211(5):835-45. doi: 10.1093/infdis/jiu525. Epub 2014 Sep 19.


Ahn D, Parker D, Planet P and Prince A. Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia. Mucosal Immunol. 2014 Nov;7(6):1366-74. doi: 10.1038/mi.2014.24. Epub 2014 Apr 16.


Parker D, Narechania A, Sebra R, Deikus G, LaRussa S, Ryan C, Smith H, Prince A, MAthema B, Ratner AJ, Kreishwirth B and Planet PJ. Genome Sequence of Bacterial Interference Strain Staphylococcus aureus 502A. Genome Announcements 2014; 2(2): e00284-14. PMCID: PMC3983310 


Parker D, Planet PJ, Soong G, Narechania A, and Prince A. Induction of type I interferon signaling determines the relative pathogenicity of Staphylococcus aureus strains. PLoS Pathog. 2014;10(2):e1003951. PMCID: PMC3930619 


Westphalen K, Gusarova GA, Islam MN, Subramanian M, Cohen TS, Prince AS, Bhattacharya J. Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature. 2014; Jan 19. doi: 10.1038/nature12902. PMID: 24463523


Planet PJ, LaRussa SJ, Dana A, Smith H, Xu A, Ryan C, Uhlemann AC, Boundy S, Goldberg J, Narechania A, Kulkarni R, Ratner AJ, Geoghegan JA, Kolokotronis SO, Prince A. Emergence of the epidemic methicillin-resistant Staphylococcus aureus strain USA300 coincides with horizontal transfer of the arginine catabolic mobile element and speG-mediated adaptations for survival on skin. MBio. 2013; Dec 17;4(6):e00889-13. doi: 10.1128/mBio.00889-13. PMID: 24345744


Cohen TS, Prince A. Bacterial pathogens activate a common inflammatory pathway through IFNλ regulation of PDCD4. PLoS Pathog. 2013; 9(10):e1003682. doi: 10.1371/journal.ppat.1003682. PMID: 24098127


Parker D, Prince A. Epithelial uptake of flagella initiates proinflammatory signaling. PLoS One. 2013;8(3):e59932.  PMCID: PMC3603936 


Cohen TS, Prince A. Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia. J Clin Invest. 2013;123(4):1630-7. PMCID: PMC3613922


Parker D, Prince A. Staphylococcus aureus Induces Type I IFN Signaling in Dendritic Cells Via TLR9. J Immunol. 2012 Oct 15;189(8):4040-6. PMCID: PMC3466375


Cohen TS, Prince A. Cystic fibrosis: a mucosal immunodeficiency syndrome. Nat Med. 2012 Apr 5;18(4):509-19.  PMCID: PMC3577071


Soong G, Chun J, Parker D, Prince A. Staphylococcus aureus activation of caspase-1/calpain signaling mediates invasion through human keratinocytes. J Infect Dis. 2012 May;205(10):1571-9. PMCID: PMC3415815


Parker D, Prince A. Immunopathogenesis of Staphylococcus aureus pulmonary infection. Semin Immunopathol 2012 Mar;34(2):281-97.  PMCID: PMC3577067 


Parker D, Prince A. Type I interferon response to extracellular bacteria in the airway epithelium. Trends Immunol. 2011 Dec;32(12):582-8.  PMCID: PMC3221817


Soong, G., F. J. Martin, J. Chun, T. S. Cohen, D. S. Ahn, and A. Prince. Staphylococcus aureus protein A mediates invasion across airway epithelial cells through activation of RhoA signaling and proteolytic activity. J Biol Chem. 2011. Oct 14; 286(41):35891-8.  PMCID: PMC3195615


Parker D, Cohen TS, Alhede M, Harfenist BS, Martin FJ, Prince A. Induction of Type I Interferon Signaling by Pseudomonas aeruginosa is Diminished in Cystic Fibrosis Epithelial Cells. Am J Respir Cell Mol Biol. 2012 Jan;46(1):6-13.  PMCID: PMC3262660


Parker D, Martin FJ, Soong G, Harfenist BS, Aguilar JL, Ratner AJ, Fitzgerald KA, Schindler C, Prince A. Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract. MBio. 2011 May 17;2(3). pii: e00016-11. PMCID: PMC3101776


Martin FJ, Parker D, Harfenist BS, Soong G, Prince A. Participation of CD11c+ leukocytes in the host response to MRSA infection of the lung. Infect Immun. 2011 79(5):1898-904.  PMCID: PMC3088152


Parker, D and Prince A. Innate Immunity in the epithelium.  Am J Respir Cell Mol Biol. 2011 45(2):189-201. PMCID: PMC3175551